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sch 772984  (MedChemExpress)


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    Structured Review

    MedChemExpress sch 772984
    Sch 772984, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 292 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sch772984+sch/SCH772984/pm41534573-58-49-53
    Average 98 stars, based on 292 article reviews
    sch 772984 - by Bioz Stars, 2026-10
    98/100 stars

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    other:

    Article Title: Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation.
    Article Snippet: Salvianolic acid B (SalB), Grammostola mechanotoxin #4 (GsMTx4), KN93, LY294002 (LY), TAE226 (TAE) and SCH772984 (SCH) were purchased from MedChemExpress (Monmouth Junction, USA).

    Article Title: Upregulation of CYP2E1 expression causes oxidative damage induced by 2-chloroethanol in primary cultured rat astrocytes.
    Article Snippet: Brain edema caused by subacute poisoning with 1,2-dichloroethane (1,2-DCE) has gained much attention during recent years, but its underlying mechanism is poorly understood.. As an intermediate metabolite of 1,2-DCE in vivo, 2-chloroethanol (2-CE) can be transformed Jo ur al Pr epr oo f into chloroacetaldehyde and reactive oxygen species (ROS) through cytochrome P450 2E1 (CYP2E1) mediated metabolism.. In previous studies, it was found that CYP2E1 expression is enhanced in the brain of mice treated with 1,2-DCE.

    Article Title: Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation
    Article Snippet: Salvianolic acid B (SalB), Grammostola mechanotoxin #4 (GsMTx4), KN93, LY294002 (LY), TAE226 (TAE) and SCH772984 (SCH) were purchased from MedChemExpress (Monmouth Junction, USA).



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    Combined ERK and AURKB inhibition slows growth of BRAF- mutant thyroid cancer cells. CUTC5 or CUTC60 were treated with ERKi-SCH, BRAFi and/or AURKBi. Phase object count was measured using the IncuCyte ZOOM live cell imaging system over 76 hrs. AUC was calculated using GraphPad Prism V8. Data shown as the mean ± SEM averaged from three experiments. *, p-value < 0.05; ***, p-value < 0.001; ****, p-value < 0.0001. ERKi-SCH: 500 nM <t>SCH772984,</t> AURKBi: 100 nM barasertib, BRAFi: 50 nM dabrafenib.
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    Image Search Results


    Combined ERK and AURKB inhibition slows growth of BRAF- mutant thyroid cancer cells. CUTC5 or CUTC60 were treated with ERKi-SCH, BRAFi and/or AURKBi. Phase object count was measured using the IncuCyte ZOOM live cell imaging system over 76 hrs. AUC was calculated using GraphPad Prism V8. Data shown as the mean ± SEM averaged from three experiments. *, p-value < 0.05; ***, p-value < 0.001; ****, p-value < 0.0001. ERKi-SCH: 500 nM SCH772984, AURKBi: 100 nM barasertib, BRAFi: 50 nM dabrafenib.

    Journal: Cancer Biology & Therapy

    Article Title: The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

    doi: 10.1080/15384047.2024.2332000

    Figure Lengend Snippet: Combined ERK and AURKB inhibition slows growth of BRAF- mutant thyroid cancer cells. CUTC5 or CUTC60 were treated with ERKi-SCH, BRAFi and/or AURKBi. Phase object count was measured using the IncuCyte ZOOM live cell imaging system over 76 hrs. AUC was calculated using GraphPad Prism V8. Data shown as the mean ± SEM averaged from three experiments. *, p-value < 0.05; ***, p-value < 0.001; ****, p-value < 0.0001. ERKi-SCH: 500 nM SCH772984, AURKBi: 100 nM barasertib, BRAFi: 50 nM dabrafenib.

    Article Snippet: SCH772984 (ERKi-SCH) was purchased from AbMole Bioscience or SelleckChem.

    Techniques: Inhibition, Mutagenesis, Live Cell Imaging

    Combined ERK and AURKB inhibition increases apoptosis. BRAF -mutant thyroid cancer cell lines (CUTC5, CUTC60) were treated with ERKi-SCH, AURKBi or the combination, as in Fig. 5. Cleaved caspase-3/7 was measured using the IncuCyte ZOOM live cell imaging over 76 hrs. Area under the curve (AUC) was calculated using GraphPad Prism and used for statistical analysis of three experiments. *, p-value < 0.1; ***, p-value < 0.001; ****, p-values < 0.0001. ERKi-SCH: 500 nM SCH772984; AURKBi: 100 nM barasertib.

    Journal: Cancer Biology & Therapy

    Article Title: The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

    doi: 10.1080/15384047.2024.2332000

    Figure Lengend Snippet: Combined ERK and AURKB inhibition increases apoptosis. BRAF -mutant thyroid cancer cell lines (CUTC5, CUTC60) were treated with ERKi-SCH, AURKBi or the combination, as in Fig. 5. Cleaved caspase-3/7 was measured using the IncuCyte ZOOM live cell imaging over 76 hrs. Area under the curve (AUC) was calculated using GraphPad Prism and used for statistical analysis of three experiments. *, p-value < 0.1; ***, p-value < 0.001; ****, p-values < 0.0001. ERKi-SCH: 500 nM SCH772984; AURKBi: 100 nM barasertib.

    Article Snippet: SCH772984 (ERKi-SCH) was purchased from AbMole Bioscience or SelleckChem.

    Techniques: Inhibition, Mutagenesis, Live Cell Imaging